In oncological, abdominal MRI, the value of motion corrected Diffusion-Weighted Imaging (DWI) including complex averaging with high and ultra-high b-values remains to be defined. This is of special importance regarding the balance between normal tissue suppression and suspicious lesion demarcation. This prospective study investigated 41 patients with an oncologically optimized prototype-DWI (with complex averaging, motion correction between averages, rescaling of motion corrupted averages, background suppression). Image quality, tissue differentiation and lesion detection/characterization were significantly increased in high (b900) as compared to ultra-high (b1500) DWI. At the same time, apparent signal-intensity ratio of lesion/normal tissue was not significantly different.