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Abstract #3448

Non-Gaussian Diffusion Imaging with a Fractional Order Calculus Model to predict response to neoadjuvant chemoradiotherapy in local advanced rectal cancer

Yanfen Cui1, Zhizheng Zhuo2, and Xiaotang Yang1

1Shanxi Province Cancer Hospital, Taiyuan, China, 2MR Clinical Sciences, Philips Healthcare Greater China, Beijing, China

A novel non-Gaussian diffusion model based on fractional order calculus (FROC) were successfully applied to diffusion MRI of rectal cancer. Statistically significant differences in △D and △β values are observed between the responder group and non- responder group (p < 0.01), indicating that FROC-derived parameters from the FROC diffusion model may be useful as imaging biomarkers in predicting the biological properties of rectal cancer in clinical practice.

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