A novel non-Gaussian diffusion model based on fractional order calculus (FROC) were successfully applied to diffusion MRI of rectal cancer. Statistically significant differences in △D and △β values are observed between the responder group and non- responder group (p < 0.01), indicating that FROC-derived parameters from the FROC diffusion model may be useful as imaging biomarkers in predicting the biological properties of rectal cancer in clinical practice.
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