Synopsis: The effect of chemo-radiation therapy on advanced head & neck squamous cell carcinoma was evaluated via diffusion and kurtosis time-dependence. We found opposing diffusion limiting regimes pre and post therapy, where prior to therapy the tissue was well described by the long-time limit (Karger Model applies), and where after therapy the tissue was well described by the short-time S/V limit. This reversal of imaging regimes can serve as a signature of the minimal effective dose required for treatment.
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