Meeting Banner
Abstract #3450

Diffusion time-dependence of diffusivity and kurtosis in locally advanced head and neck squamous cell carcinoma before and after chemo-radiation therapy

Gregory Lemberskiy1, Steven Baete1, Dmitry S Novikov1, Els Fieremans1, Elcin Zan1, Kenneth Hu2, and Sungheon Gene Kim1

1Radiology, NYU School of Medicine, New York, NY, United States, 2Radiation Oncology, NYU Langone Health, New York, NY, United States

Synopsis: The effect of chemo-radiation therapy on advanced head & neck squamous cell carcinoma was evaluated via diffusion and kurtosis time-dependence. We found opposing diffusion limiting regimes pre and post therapy, where prior to therapy the tissue was well described by the long-time limit (Karger Model applies), and where after therapy the tissue was well described by the short-time S/V limit. This reversal of imaging regimes can serve as a signature of the minimal effective dose required for treatment.

This abstract and the presentation materials are available to members only; a login is required.

Join Here