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Abstract #3457

Adapting Diffusion Weighted Arterial Spin Labelling (DWASL) to use a Single Sided Bipolar Diffusion Gradient to Probe Microvascular Signal

Samantha Paterson1, Antoine Vallatos2, and William Holmes3

1Neuroscience & Psychology, University of Glasgow, Glasgow, United Kingdom, 2University of Edinburgh, Edinburgh, United Kingdom, 3University of Glasgow, Glasgow, United Kingdom

Diffusion Weighted Arterial Spin Labelling uses a pair of bipolar diffusion gradients surrounding a spin echo pulse to image signal in the intravascular and extravascular compartments. We propose moving these gradients to a single sided gradient, reducing Δ and changing where the change to the extravascualar signal starts. Our results show that the ratio has changed from b = 50 to b = 300 s/mm2 for our new single sided sequence. This can give us more information on the intravascular signal, helping to improve the probing of blood brain barrier permeability.

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