Abstract #3458

Differentiation of Sinonasal Mucosal Malignant Melanomas from Sinonasal Carcinomas Using Whole-tumour Histogram Analysis of Diffusion Kurtosis Imaging and Intravoxel Incoherent Motion

Zebin Xiao¹, Zuohua Tang², Jing Zhang³, Guang Yang³, Yang Song³, Linying Guo², and Zhongshuai Zhang⁴

¹Eye & ENT Hospital of Fudan University, Shanghai, China, ²Radiology, Eye & ENT Hospital of Fudan University, Shanghai, China, ³Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China, ⁴MR Scientific Marketing, Siemens Healthcare, Shanghai, China

This is the first study that used histogram metrics derived from diffusion kurtosis (DKI) and intravoxel incoherent motion (IVIM) to differentiate sinonasal mucosal malignant melanomas (SNMMMs) and squamous cell carcinomas (SCCs) which are sometimes indistinguishable with conventional MRI. Overall, histogram metrics obtained from K, D, D* and f were found to be significantly higher in SNMMMs than in SCCs. Furthermore, the combined use of the two independent indicators, the 75th percentile of K and skewness of D, can effectively differentiate between SNMMMs and SCCs.

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