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Abstract #3462

Brain Development in Non-human Primates Assessed with Neurite Orientation Dispersion and Density Imaging

Mayu Iida1,2, Junichi Hata2,3,4, Marin Nishio1,2,3, Fumiko Seki2,3,4, Yawara Haga1,3,4, Erika Sasaki2,3, and Takako Shirakawa1

1Department of Radiological Sciences, Human Health Sciences, Tokyo Metropolitan University Graduate School, Tokyo, Japan, 2Live Imaging Center, Central Institute for Experimental Animals, Kanagawa, Japan, 3Department of Physiology, Keio University School of Medicine, Tokyo, Japan, 4Laboratory for Marmoset Neural Architecture, Center for Brain Science, RIKEN, Saitama, Japan

Neurite orientation dispersion and density imaging (NODDI) can specifically estimate the microstructure of neurites. Brain development characteristics were evaluated using NODDI in common marmosets. The study included six common marmosets (age, 5–30 months). In NODDI, the value of both dispersion and density increased. Additionally, the trend of increase varied from region to region. This pattern has previously been observed in human studies. Thus, NODDI can be a good approach to evaluate brain development in the common marmoset, and eventually a suitable parameter to study brain developmental disorders for diagnosis and treatment.

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