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Abstract #3461

Assessment of microstructural changes during intervertebral disc degeneration by diffusion kurtosis imaging

Li LI1,2, Jicheng Fang1, Alessandro Scotti,2, Kejia Cai2, and WenZhen Zhu1

1Radiological Department, Tongji Hospital, Tongji Medical College, HUST, Wuhan, China, 21.Radiology Dept., 2. Bioengineering Dept., College of Medicine, University of Illinois at Chicago, Chicago, IL, United States

To assess the microstructural changes of intervertebral disc degeneration, 18 rats were punctured percutaneously at the intervertebral disc, and the rats’ tail was imaged with T2WI, DWI and DKI sequences. The diffusion parameters changes were consistent with the histological changes at the different time points and showed significant differences between the different groups. And, DKI parameters were better markers to detect the change of microstructure of the degenerated discs than conventional DWI. Therefore, DKI is a noninvasive technique to test the changes of the microstructure of the intervertebral discs.

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