Abstract #3471

Diffusion kurtosis imaging–derived histogram metrics for prediction of KRAS/NRAS/BRAF mutations in rectal adenocarcinoma: Preliminary findings

Yanfen Cui¹, Zhizheng Zhuo², and Xiaotang Yang¹

¹Shanxi Province Cancer Hospital, Taiyuan, China, ²MR Clinical Sciences, Philips Healthcare Greater China, Beijing, China

It was revealed that DKI metrics with whole-tumor volume histogram analysis, especially the K75th parameter, yielded more preferable AUC and specificity values for predicting KRAS/NRAS/BRAF mutations than ADC and D values, and thus may potentially serve as an optimal imaging biomarker for the prediction of KRAS/NRAS/BRAF mutations for guiding targeted therapy.

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