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Abstract #3492

Optimized diffusion gradient waveforms for estimating surface-to-volume ratio of an anisotropic medium

Nicolas Moutal1, Ivan I. Maximov2,3, and Denis S. Grebenkov1

1Laboratoire PMC, Ecole Polytechnique, Palaiseau, France, 2NORMENT, KG Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway, 3Institute of Clinical Medicine, University of Oslo, Oslo, Norway

We present here a simple and efficient algorithm for designing of diffusion gradient profiles allowing one to implement prescribed theoretical properties. This algorithm generalizes the well-known sine and cosine decomposition and can handle various experimental constraints. Relying on recent diffusion MRI theoretical advances, we apply it to the challenging problem of estimating the surface-to-volume ratios in anisotropic media.

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