Abstract #3492

Optimized diffusion gradient waveforms for estimating surface-to-volume ratio of an anisotropic medium

Nicolas Moutal¹, Ivan I. Maximov^2,3, and Denis S. Grebenkov¹

¹Laboratoire PMC, Ecole Polytechnique, Palaiseau, France, ²NORMENT, KG Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway, ³Institute of Clinical Medicine, University of Oslo, Oslo, Norway

We present here a simple and efficient algorithm for designing of diffusion gradient profiles allowing one to implement prescribed theoretical properties. This algorithm generalizes the well-known sine and cosine decomposition and can handle various experimental constraints. Relying on recent diffusion MRI theoretical advances, we apply it to the challenging problem of estimating the surface-to-volume ratios in anisotropic media.

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