Oscillating-gradient spin-echo (OGSE) diffusion tensor MRI permits very short diffusion times (e.g. 5 ms) relative to the typical pulsed-gradient spin-echo (PGSE), but it is challenging to acquire in the human brain. Given low b-values and spatial resolution, it is more prone to problematic artifacts such as Gibbs ringing and partial-volume effects that can compromise diffusion parameter measurements. It is shown here that the use of inversion-recovery FLAIR to suppress cerebrospinal fluid can significantly reduce such artifacts, improve overall image/map quality, and provide better quantitation of OGSE-PGSE diffusion parameter differences in the white matter of the human brain.
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