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Abstract #3493

Oscillating Gradient Spin-Echo Diffusion Tensor Imaging of the Human Brain using FLAIR

Fernanda Padron1, Thorsten Feiweier2, and Christian Beaulieu1

1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Siemens Healthcare GmbH, Erlangen, Germany

Oscillating-gradient spin-echo (OGSE) diffusion tensor MRI permits very short diffusion times (e.g. 5 ms) relative to the typical pulsed-gradient spin-echo (PGSE), but it is challenging to acquire in the human brain. Given low b-values and spatial resolution, it is more prone to problematic artifacts such as Gibbs ringing and partial-volume effects that can compromise diffusion parameter measurements. It is shown here that the use of inversion-recovery FLAIR to suppress cerebrospinal fluid can significantly reduce such artifacts, improve overall image/map quality, and provide better quantitation of OGSE-PGSE diffusion parameter differences in the white matter of the human brain.

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