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Abstract #3503

Reducing spectral anisotropy in isotropic b-tensor multidimensional diffusion encoding

Henrik Lundell1, Markus Nilsson2, Filip Szczepankiewicz3,4,5, Carl-Fredrik Westin3,6, Daniel Topgaard7, and Samo Lasič8

1Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 2Clinical Sciences, Department of Radiology, Lund University, Lund, Denmark, 3Brigham and Women’s Hospital, Boston, MA, United States, 4Harvard Medical School, Boston, Denmark, 5Department of Radiology, Lund University, Lund, Denmark, 6Harvard Medical School, Boston, MA, United States, 7Division of Physical Chemistry, Department of Chemistry, Lund University, Lund, Sweden, 8Random Walk Imaging AB, Lund, Sweden

Multidimensional diffusion encoding isotropic b-tensors eliminate rotational variance from anisotropic Gaussian diffusion, an essential feature for estimating microscopic anisotropy. In anisotropic substrates which exhibit non-Gaussian diffusion on the time scale of the encoding pulse, the variance in temporal characteristics of diffusion encoding across different directions – spectral anisotropy (SA) - may introduce a directional variance in apparent diffusivities. We propose an alternative isotropic encoding with drastically lower SA, which in turn allows accessing intrinsic signatures of non-Gaussian diffusion.

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