In contrast to fractional anisotropy, microscopic diffusion anisotropy allows measurement of pore structural anisotropy with no influence from orientational coherence. However, acquisitions that allow in vivo measurement of microscopic anisotropy are generally time-consuming and/or low SNR. Here, we introduce an efficient approach to perform isotropic diffusion encoding and measure high quality full-brain microscopic anisotropy in a scan time of only 3 minutes at 7T. Results are demonstrated in a healthy subject and MS patient, where clear delineation of lesions is observed in the latter case.
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