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Abstract #3502

Towards clinically viable and robust measurement of microscopic diffusion anisotropy

Nico J. J. Arezza1,2, Aidin Arbabi2, and Corey A. Baron1,2

1Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, 2Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University, London, ON, Canada

In contrast to fractional anisotropy, microscopic diffusion anisotropy allows measurement of pore structural anisotropy with no influence from orientational coherence. However, acquisitions that allow in vivo measurement of microscopic anisotropy are generally time-consuming and/or low SNR. Here, we introduce an efficient approach to perform isotropic diffusion encoding and measure high quality full-brain microscopic anisotropy in a scan time of only 3 minutes at 7T. Results are demonstrated in a healthy subject and MS patient, where clear delineation of lesions is observed in the latter case.

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