Abstract #3505

3D distortion-free multi-slab diffusion-prepared magnitude-stabilized bSSFP imaging

Yu Gao^1,2, Ziwu Zhou¹, Xinyu Ye³, Hua Guo³, Yingli Yang^2,4, and Peng Hu^1,2

¹Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Physics and Biology in Medicine IDP, University of California, Los Angeles, Los Angeles, CA, United States, ³Biomedical Engineering, Tsinghua University, Beijing, China, ⁴Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United States

A 3D diffusion-prepared magnitude-stabilized bSSFP (DP-MS-bSSFP) sequence was proposed and validated to achieve high resolution distortion-free brain diffusion imaging. Shot-to-shot phase variation was corrected using the plane-by-plane MUSE technique. High-quality 3D diffusion images, ADC maps and cFA maps were obtained from four volunteers. Good agreement of white matter ADC between DW-ssEPI and DP-MS-bSSFP was observed based on the Bland-Altman plot. Geometric accuracy of DP-MS-bSSFP was confirmed by a four-fold reduction of target registration error compared with DW-ssEPI. In conclusion, the proposed DP-MS-bSSFP approach provided high-quality 3D diffusion images and diffusion tensor images with high ADC accuracy and minimal distortion.

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