Abstract #3506

In-vivo Diffusion Exchange Spectroscopy (DEXSY), to measure water exchange in tumours.

James Olav Breen-Norris^1,2, Bernard Siow^1,2,3, Claire Walsh¹, Mark F. Lythgoe¹, Andrada Ianus², Daniel C. Alexander², and Simon Walker-Samuel¹

¹Centre for Advanced Biomedical Imaging, Division of Medicine, UCL, London, United Kingdom, ²Microstructure Imaging Group, Centre for Medical Image Computing, Department of Computer Science, UCL, London, United Kingdom, ³The Francis CRICK institute, London, United Kingdom

We describe the first use of Diffusion Exchange Spectroscopy (DEXSY) in-vivo, to measure water exchange in tumours. We present preliminary data suggesting that we can capture information about the micro-structure of tumors, with what appear to be intracellular, extracellular and perfusion peaks present in diffusion-diffusion exchange plots, acquired from subcutaneous tumor xenograft models, in-vivo using DEXSY.

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