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Abstract #3510

Multi-Echo Segmented Diffusion-Weighted MRI for Ex-Vivo Whole-Brain Measurements with 300mT/m Gradients

Cornelius Eichner1, Toralf Mildner1, Michael Paquette1, Torsten Schlumm1, Catherine Crockford2, Roman Wittig2, Evgeniya Kirilina1, Carsten Jäger1, Harald E. Möller1, Nikolaus Weiskopf1, Angela Friederici1, and Alfred Anwander1

1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany

We provide a novel method to increase SNR of segmented diffusion-weighted EPI acquisitions. Multiple gradient echoes were acquired after each diffusion-preparation and combined in an SNR-optimized way using weightings from quantitative T2* maps. The combination of diffusion-weighted echoes yielded an SNR-gain of 58% compared to single-echo dMRI data with an increase in the segmented readout duration by only 23.1 ms. The multi-echo diffusion MRI acquisition and combination were employed to acquire high-quality ex-vivo diffusion-weighted MRI data from a wild chimpanzee brain.

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