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Abstract #3512

Effects of imperfect slice separation in simultaneous multi-slice for diffusion kurtosis imaging

L. Tugan Muftuler1,2, Daniel V. Olson3, Volkan Emre Arpinar2,4, and Andrew S. Nencka2,4

1Department of Neurosurgery, Medical College of Wisconsins, Milwaukee, WI, United States, 2Center for Imaging Research, Medical College of Wisconsin, Milwaukee, WI, United States, 3Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, 4Department of Radiology, Medical College of Wisconsin, Milwaukee, WI, United States

Simultaneous multislice (SMS) technique accelerates MRI data acquisition. However, slice separation in reconstruction is imperfect. This results in residual leakage between the simultaneously excited slices. For diffusion MRI, repeated pairing of the same slices in the image series leads to repeated leakage of a consistent diffusion signal from the other slice. Studies of this effect on diffusion MRI is sparse. Here, we tested two different SMS acquisition and image reconstruction techniques and quantified resulting errors on all diffusion kurtosis (DKI) metrics in different ROIs. Large errors were observed with SMS compared to singleband acquisitions for all DTI and DKI metrics

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