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Abstract #3519

3D distortion-free diffusion imaging using an accelerated multi-shot diffusion-prepared sequence

Elisa Roccia1, Radhouene Neji1,2, Vicky Goh3, and Isabel Dregely1

1Biomedical Engineering, King's College London, London, United Kingdom, 2Siemens Healthcare, Frimley, United Kingdom, 3Cancer Imaging, King's College London, London, United Kingdom

Current methods for cancer diffusion imaging employ 2D single-shot diffusion weighted echo planar imaging sequences, which are fast but have limited resolution and are prone to distortion artefacts. The purpose of this work is to achieve 3D high-resolution and distortion-free diffusion imaging suitable for cancer precision diagnostics and therapy planning. A multi-shot diffusion-prepared sequence with gradient echo readout, centric encoding, and accelerated variable density acquisition was developed and tested in healthy volunteer brains as an exemplar. A full set of 2.2-fold accelerated diffusion weighted images in three diffusion directions was acquired in 4:30 min producing quantitative 3D distortion-free ADC maps.

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