Current methods for cancer diffusion imaging employ 2D single-shot diffusion weighted echo planar imaging sequences, which are fast but have limited resolution and are prone to distortion artefacts. The purpose of this work is to achieve 3D high-resolution and distortion-free diffusion imaging suitable for cancer precision diagnostics and therapy planning. A multi-shot diffusion-prepared sequence with gradient echo readout, centric encoding, and accelerated variable density acquisition was developed and tested in healthy volunteer brains as an exemplar. A full set of 2.2-fold accelerated diffusion weighted images in three diffusion directions was acquired in 4:30 min producing quantitative 3D distortion-free ADC maps.
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