Hyperpolarized gas pulmonary MRI provides physiologically relevant biomarkers of obstructive lung disease including emphysema, bronchopulmonary dysplasia, congenital lobar emphysema and alpha-1 antitrypsin deficiency. Recently, a stretched-exponential-model combined with under-sampling in the imaging and diffusion direction was used for the generation of 3He static-ventilation, T2* and multiple b-value diffusion-weighted MRI-based ADC/morphometry maps. We hypothesize that the 3He method can be modified to provide whole lung 129Xe MRI-based emphysema biomarkers including static-ventilation, T2*/ADC/morphometry maps with high-spatial-image-resolution in a single breath-hold. Therefore, in this proof-of-concept evaluation, our objective was to demonstrate a feasibility of this approach in a small group of patients.
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