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Abstract #3518

Feasibility of 129Xe MRI Morphometry Measurements with Acceleration Factors of 7 and 10

Alexei Ouriadov1, Andrew Ross Westcott1,2, David G McCormack3, and Grace Parraga1,2,3

1Robarts Research Institute, London, ON, Canada, 2Department of Medical Biophysics, Western University, London, ON, Canada, 3Division of Respirology, Department of Medicine, Western University, London, ON, Canada

Hyperpolarized gas pulmonary MRI provides physiologically relevant biomarkers of obstructive lung disease including emphysema, bronchopulmonary dysplasia, congenital lobar emphysema and alpha-1 antitrypsin deficiency. Recently, a stretched-exponential-model combined with under-sampling in the imaging and diffusion direction was used for the generation of 3He static-ventilation, T2* and multiple b-value diffusion-weighted MRI-based ADC/morphometry maps. We hypothesize that the 3He method can be modified to provide whole lung 129Xe MRI-based emphysema biomarkers including static-ventilation, T2*/ADC/morphometry maps with high-spatial-image-resolution in a single breath-hold. Therefore, in this proof-of-concept evaluation, our objective was to demonstrate a feasibility of this approach in a small group of patients.

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