Abstract #3518

Feasibility of 129Xe MRI Morphometry Measurements with Acceleration Factors of 7 and 10

Alexei Ouriadov¹, Andrew Ross Westcott^1,2, David G McCormack³, and Grace Parraga^1,2,3

¹Robarts Research Institute, London, ON, Canada, ²Department of Medical Biophysics, Western University, London, ON, Canada, ³Division of Respirology, Department of Medicine, Western University, London, ON, Canada

Hyperpolarized gas pulmonary MRI provides physiologically relevant biomarkers of obstructive lung disease including emphysema, bronchopulmonary dysplasia, congenital lobar emphysema and alpha-1 antitrypsin deficiency. Recently, a stretched-exponential-model combined with under-sampling in the imaging and diffusion direction was used for the generation of ³He static-ventilation, T₂* and multiple b-value diffusion-weighted MRI-based ADC/morphometry maps. We hypothesize that the ³He method can be modified to provide whole lung ¹²⁹Xe MRI-based emphysema biomarkers including static-ventilation, T₂*/ADC/morphometry maps with high-spatial-image-resolution in a single breath-hold. Therefore, in this proof-of-concept evaluation, our objective was to demonstrate a feasibility of this approach in a small group of patients.

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