Meeting Banner
Abstract #3555

Delineation of white matter microstructural maturation of infant brain with DKI

Chenying Zhao1,2, Minhui Ouyang2, Michelle A Slinger2, and Hao Huang2,3

1Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States, 3Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Diffusion kurtosis imaging (DKI) based on multi-shell diffusion MRI may offer extra information on WM microstructural complexity changes during infant development compared to conventional DTI. After acquiring DKI and DTI from 18 normal infants aged 0-1 year, we measured the mean kurtosis (MK) and fractional anisotropy (FA) of all major WM tracts by combining WM skeletonization process and WM tract labels. Significant age-related increases in both MK and FA were found in all tracts. Distinctive developmental trajectories of WM tracts with MK measurements compared to those with FA measurements were revealed, indicating heterogeneous increases of microstructural complexity among WM tracts.

This abstract and the presentation materials are available to members only; a login is required.

Join Here