Cell compartments can present non-uniform T2 relaxations, depending on tissue properties. The non-uniform T2 relaxation has been shown to affect measurements of apparent diffusion coefficients (ADC). In additional to ADC, diffusion heterogeneity measured by modeling non-monoexponential decay has been used to characterize water diffusion in tissue microstructure. The purpose of this study is to study the effects of non-uniform T2 relaxations on the diffusion heterogeneity using a Monte Carlo simulation. The results demonstrate that the diffusion heterogeneity may provide more information about water diffusion within microstructure with non-uniform T2 relaxations.