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Abstract #3553

Diffusion Kurtosis Imaging (DKI) Biomarkers correlate with dysfunction in the EAE model of MS

Andrey Chuhutin1, Brian Hansen1, Agnieszka Wlodarczyk2, Trevor Owens2, Noam Shemesh3, and Sune Nørhøj Jespersen1,4

1CFIN, Aarhus University, Aarhus, Denmark, 2Department of Neurobiology Research, Institute for Molecular Medicine,University of South Denmark, Odense, Denmark, 3Champalimaud Center for Unknown, Lisbon, Portugal, 4Dept. of Physics and Astronomy, Aarhus University, Aarhus, Denmark

To study the relationship between microstructure and disability, 18 ex-vivo spinal cords from a mouse model of MS (EAE) were investigated using DKI and a biophysical model of diffusion. Diffusion data were acquired together with T2* images to delineate lesions. Kurtosis tensors and microstructural parameters were used for statistical analysis using a LME model. The results show a strong relation between disability and kurtosis tensor parameters similar to observations in other hypomyelinating MS models and in patients. Conversely, changes in model parameters, such as extra-axonal axial diffusivity, are clearly different from previous studies using other animal models of MS.

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