Abstract #3553

Diffusion Kurtosis Imaging (DKI) Biomarkers correlate with dysfunction in the EAE model of MS

Andrey Chuhutin¹, Brian Hansen¹, Agnieszka Wlodarczyk², Trevor Owens², Noam Shemesh³, and Sune Nørhøj Jespersen^1,4

¹CFIN, Aarhus University, Aarhus, Denmark, ²Department of Neurobiology Research, Institute for Molecular Medicine,University of South Denmark, Odense, Denmark, ³Champalimaud Center for Unknown, Lisbon, Portugal, ⁴Dept. of Physics and Astronomy, Aarhus University, Aarhus, Denmark

To study the relationship between microstructure and disability, 18 ex-vivo spinal cords from a mouse model of MS (EAE) were investigated using DKI and a biophysical model of diffusion. Diffusion data were acquired together with T2* images to delineate lesions. Kurtosis tensors and microstructural parameters were used for statistical analysis using a LME model. The results show a strong relation between disability and kurtosis tensor parameters similar to observations in other hypomyelinating MS models and in patients. Conversely, changes in model parameters, such as extra-axonal axial diffusivity, are clearly different from previous studies using other animal models of MS.

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