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Abstract #3552

Reliability of microstructural quantification with diffusion MRI in brain tumors.

Umberto Villani1,2, Erica Silvestri1,2, Marco Castellaro1,2, Maurizio Corbetta1,3, and Alessandra Bertoldo1,2

1Padova Neuroscience Center, University of Padova, Padova, Italy, 2Department of Information Engineering, University of Padova, Padova, Italy, 3Department of Neuroscience, University of Padova, Padova, Italy

Most existing biophysical models used to quantify diffusion microstructural information are designed for the healthy brain. When pathological processes occur, the diffusion signal of cancerous regions is altered, possibly biasing the fitting results of these models and making their parameter estimates unreliable. In this work, we investigate the precision and accuracy of estimates provided by several well known diffusion models, by evaluating their goodness-of-fit with residual sum of squares map and the parameter reliability with the bootstrap technique.

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