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Abstract #3572

Diffusion time dependence in the mid-time regime: a simulation study using PGSE.

Annelinde Buikema1, Arjan den Dekker1,2, and Jan Sijbers1

1imec-Visionlab, Department of Physics, University of Antwerp, Antwerp, Belgium, 2Delft Center for Systems and Control, Delft University of Technology, Delft, Netherlands

The purpose of this work is to study the effect of varying the diffusion time on the estimation of the parameters of the two-compartment diffusion tensor model in the mid-time regime. Simulation results show that the precision of the diffusion time-dependent compartmental parameter estimates increases when a variable echo time acquisition scheme is used. At low SNR, however, including diffusion time-dependence may lead to a high bias and variance compared to the more conventional non diffusion time-dependent model.

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