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Abstract #3584

Joint distribution of axonal length and diameter quantifies beading in traumatic brain injury

Dan Benjamini1,2, Michal E Komlosh1,2, Elizabeth B Hutchinson1, and Peter J Basser1

1National Institutes of Health, Bethesda, MD, United States, 2Center for Neuroscience and Regenerative Medicine, Bethesda, MD, United States

We present a novel diffusion MRI approach to measure the three-dimensional axonal morphology alterations following traumatic brain injury that results in beading, by modeling axons with a two-dimensional joint distribution of diameters and lengths ($$$D$$$-$$$L$$$). Here we study a segment of ferret spinal cord tissue with known and focal Wallerian degeneration of the corticospinal tract alongside an uninjured control. The results suggest that this approach can be used to specifically detect and quantify axonal beading.

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