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Abstract #3585

Quantitative Sodium Pump Activity, Cellularity, and Cytometry: In Vivo Analytical Pathology from DWI

Eric M. Baker1, Brendan Moloney1, Xin Li1, Gregory J. Wilson2, Thomas M. Barbara1, Jeffrey H. Maki3, Erin W. Gilbert4, and Charles S. Springer, Jr.1

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2Home, Mill Creek, WA, United States, 3Radiology, University of Colorado Denver, Aurora, CO, United States, 4Surgery, Oregon Health & Science University, Portland, OR, United States

With cellular ensembles featuring stochastic geometries, Monte Carlo random walk simulated DWI b-space decays exhibit sensitivity to cell biology parameters measuring membrane Na+,K+‑ATPase [NKA] activity, cell density, ρ, and voxel average cell volume, <V>. Furthermore, the simulation matching the experimental in vivo human cerebral cortex b‑space decay has parameters [cellular water efflux rate constant <kio> = 2 s-1, ρ = 98,000 cells/μL, and <V> = 8.2 pL] in near absolute agreement with the most pertinent literature. Inspecting the common, empirical early decay measure, ADC, of these simulations provides insights into acute and chronic tissue property changes in vivo.

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