With cellular ensembles featuring stochastic geometries, Monte Carlo random walk simulated DWI b-space decays exhibit sensitivity to cell biology parameters measuring membrane Na+,K+‑ATPase [NKA] activity, cell density, ρ, and voxel average cell volume, <V>. Furthermore, the simulation matching the experimental in vivo human cerebral cortex b‑space decay has parameters [cellular water efflux rate constant <kio> = 2 s-1, ρ = 98,000 cells/μL, and <V> = 8.2 pL] in near absolute agreement with the most pertinent literature. Inspecting the common, empirical early decay measure, ADC, of these simulations provides insights into acute and chronic tissue property changes in vivo.
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