Abstract #3586

Investigation of relationships between systemic inflammation and brain structure in chronic obstructive pulmonary disease (COPD)

Mohani-Preet K Bajaj¹, Sachelle Ruickbie², Daniel R Burrage², Catherine A Spilling³, Abhiram Prasad⁴, James Dodd⁵, Paul W Jones⁶, Emma H Baker⁶, and Thomas R Barrick³

¹Neurosciences Research Centre, Molecular and Clinical Research Institute, St George’s Uni, Neurosciences Research Centre, Molecular and Clinical Research Institute, St George’s, University of London, London, United Kingdom, ²Institute for Infection and Immunity, St George's University of London, London, United Kingdom, Institute for Infection and Immunity, St George's, University of London, London, United Kingdom, ³Neurosciences Research Centre, Molecular and Clinical Research Institute, St George’s, University of London, Neurosciences Research Centre, Molecular and Clinical Research Institute, St George’s, University of London, London, United Kingdom, ⁴St George’s, University of London, London, United Kingdom, ⁵Academic Respiratory Unit, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom, Bristol, United Kingdom, ⁶Institute for Infection and Immunity, St George's, University of London, London, United Kingdom

COPD patients have increased systemic inflammation and increased structural brain damage. 23 COPD patients with coronary artery disease (CAD), and 24 people without COPD matched for smoking, and CAD severity (Gensini score) were studied. COPD patients had more white matter lesions and microstructural tract abnormalities compared to controls. Systemic inflammation (high sensitivity C-reactive protein and fibrinogen) was associated with microstructural brain damage in whole-group analyses. These results suggest a systemic inflammatory process in COPD, which may contribute to white matter abnormalities, consistent with those reported in small vessel disease.

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