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Abstract #3587

Q-Space Trajectory Imaging to Untangle Sources of Microstructural White Matter Changes: Comparison of Schizophrenia Subjects and Healthy Controls

Ofer Pasternak1, Filip Szczepankiewicz1, Zora Kikinis1, Markus Nilsson2, Tomáš Kašpárek3,4, and Carl-Fredrik Westin1

1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 2Lund University, Lund, Sweden, 3University Hospital Brno, Brno, Czech Republic, 4Masaryk University, Brno, Czech Republic

The recently proposed q-space trajectory imaging (QTI) analysis for multidimensional dMRI acquisitions with free wave forms quantifies domains of variability (size, shape, orientation) that can explain the sources of microstructural changes in the brain. These previously inaccessible domains are used here to disentangle differences observed in the white matter of schizophrenia patients compared to healthy controls. In this population microscopic anisotropy (shape variability) explains changes in fractional anisotropy, in agreement with a hypothesis of white matter degeneration. This study provides a first proof of principal for the feasibility of applying free wave form based sequences on a clinical population.

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