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Abstract #3594

Longitudinal evaluation of bundle-wise water diffusion changes following axonal degeneration in a region of fiber crossing

Omar Narvaez1, Ricardo Coronado-Leija1, Gilberto Rojas-Vite1, Marcos Aranda2, Alonso Ramirez-Manzanares3, Jose Luis Marroquin3, Jorge Larriva-Sahd1, and Luis Concha1

1Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro, Mexico, 2Escuela de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina, 3Centro de Investigacion en Matematicas, Guanajuato, Mexico

Axonal degeneration is a hallmark of many neuropathologies, with a defined time course presenting distinct histological features. In single fiber regions, the tensor model provides reliable information in early and chronic phases of axonal damage. However, said model cannot accurately determine per-bundle characteristics in voxels occupied by axonal populations with different orientations. We evaluated two multiple-fiber methods in an animal model of axonal degeneration (unilateral retinal ischemia) to provide information about the sensitivity of these models related to microstructural changes occuring in the acute and early chronic stages of pathology in a crossing fiber region.

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