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Abstract #3595

Towards MR-based interrogation of the hypoxia-driven insulin resistance mechanism: Adipocytes size estimation.

Darya Morozov1, Alexander L. Sukstanskii1, and Scott C. Beeman1

1Radiology, Washington University in St. Louis, School of Medicine, St. Louis, MO, United States

It has been suggested that adipocyte hypertrophy plays a key role in the pathogenesis of systemic insulin resistance and type 2 diabetes. A method for quantifying adipocyte size/hypertrophy in-vivo would be a major advance towards understanding the pathogenesis of type 2 diabetes. In-vivo quantification of adipocyte size might be achievable using short time regime diffusion MR, which carries information about size of the system. Herein, we explore the feasibility of measuring adipocyte size based on the diffusion of triglyceride within adipocytes and the principles of the short diffusion time regime.

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