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Abstract #3601

Free Water Characterization of Peritumoral Regions in Primary and Secondary Brain Neoplasms

Abdol Aziz Ould Ismail1, Drew Parker1, Simon Alexander2, Steven Brem3, and Ragini Verma1

1Penn Patho-Connectomics Lab, Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Synaptive Medical, Victoria, BC, Canada, 3Neurosurgical Oncology, University of Pennsylvania, Philadelphia, PA, United States

There is a growing interest in characterizing the peritumoral regions in neoplasms, in order to distinguish primary and secondary neoplasms, improve tractography for surgical planning, and create radiomic markers of infiltration. Free water estimation is expected to reflect the differences in water content of the peritumoral region between these tumor types. In this work, we compare glioblastoma (primary) and metastatic (secondary) tumors based on their free water estimated using standard clinical diffusion MRI (dMRI). Results demonstrate significant difference in these tumor types based on the free water measures, fractional anisotropy post-correction and the coverage of the peritumoral region by tractography.

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