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Abstract #3602

Diffusion Weighted MRI Characterization of Effects of Sex and APOE Genotype in a Mouse Model

Loi Vinh Do1, Adam Scott Bernstein1, Aarti Mishra2,3, Maunil K Desai2, Marc Lindley1, Chidi Ugonna1, Nan-kuei Chen1, Roberta Brinton3,4, and Theodore Trouard1

1Biomedical Engineering, University of Arizona, Tucson, AZ, United States, 2Department of Clinical Therapeutics, USC School of Pharmacy, University of Southern California, Los Angeles, CA, United States, 3Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States, 4Department of Pharmacology, University of Arizona, Tucson, AZ, United States

Structural and diffusion MRI (dMRI) analyses can be used to characterize neurodegeneration during Alzheimer’s disease progression. Male and female mice with a targeted replacement of mouse APOE gene with humanized APOEε3 or APOEε4, underwent behavioral, transcriptomic and imaging analyses. Postmortem MRI of fixed brains included high resolution T2-weighted and diffusion weighted imaging. Structural volume assessment revealed that APOE genotype and sex have a significant impact on regional brain volumes. dMRI quantified white matter microstructural differences between APOEε3 or APOEε4 females/males which maybe cross-validated with transcriptomic and behavioral findings. Further confirmation of microstructural assessment is pending by electron micrographs.

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