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Abstract #3605

High B-value In-vivo DTI for Early Detection of Cerebral Microstructure Alteration: Application to Hippocampus Lesions in a Mouse Model of Multiple Sclerosis

Renaud NICOLAS1, Amandine CROMBE2,3, Nathalie RICHARD4, Thomas TOURDIAS2,3, and Bassem HIBA4

1INCIA, Université de Bordeaux, CNRS, Bordeaux, France, Metropolitan, 2Neurocentre Magendie, INSERM, U1215, Bordeaux, France, Metropolitan, 3CHU de Bordeaux, Bordeaux, France, Metropolitan, 4Institut des sciences cognitives Marc Jeannerod, UMR 5229, CNRS-université Lyon1, Bron, France, Metropolitan

Few reports have highlighted the value of DTI achieved with a strong water-diffusion weighting to capture early and diffuse changes in cerebral microstructure of the white-matter. This study investigates the benefit of DTI with b-value=2700s/mm² to detect microstructure lesions of the hippocampus in a mouse model of multi-sclerosis. High b-value DTI allowed to detect microstructure changes invisible using DTI achieved with classical b-value=1000s/mm². In grey-matter tissues with complex architecture such as hippocampus, an increase of b-value appeared to be more relevant to monitor the microstructure changes compared to an increase of the number of diffusion directions.

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