Few reports have highlighted the value of DTI achieved with a strong water-diffusion weighting to capture early and diffuse changes in cerebral microstructure of the white-matter. This study investigates the benefit of DTI with b-value=2700s/mm² to detect microstructure lesions of the hippocampus in a mouse model of multi-sclerosis. High b-value DTI allowed to detect microstructure changes invisible using DTI achieved with classical b-value=1000s/mm². In grey-matter tissues with complex architecture such as hippocampus, an increase of b-value appeared to be more relevant to monitor the microstructure changes compared to an increase of the number of diffusion directions.
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