Abstract #3606

Diffusional Kurtosis Imaging of Temporal Lobe Gray Matter as a Biomarker of Neurological Disease: Schizophrenia and Autism Spectrum Disorder

Faye McKenna^1,2, Laura Miles¹, Jeffrey Donaldson¹, F. Xavier Castellanos³, Donald Goff³, and Mariana Lazar¹

¹Radiology, Center for Biomedical Imaging, New York, NY, United States, ²Sackler Institute of Graduate Biomedical Sciences, New York, NY, United States, ³Psychiatry, New York University School of Medicine, New York, NY, United States

In this study, we employed diffusion kurtosis imaging (DKI) to test for differences in gray matter (GM) microstructure in schizophrenia (SZ) and autism spectrum disorder (ASD). Significantly increased metrics of DKI were found in SZ compared to HC participants, while significantly decreased metrics of DKI were found in ASD compared to HC in the temporal lobe and sub-lobar temporal regions of interest (ROIs). In vivo DKI metrics appear to be sensitive to GM microstructural pathology in SZ and ASD and may provide new information on the neural underpinnings of these disorders.

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