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Abstract #3607

Resting-state diffusion fMRI bears strong resemblance and only subtle differences to BOLD fMRI

Ileana Ozana Jelescu1

1Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Diffusion fMRI (dfMRI) is a presumably non-BOLD technique sensitive to transient microstructural changes underlying neural activity. Previous task-fMRI studies have assessed the characteristics of the dfMRI signal and potential BOLD contamination, with conflicting results. Here we acquired resting-state fMRI data with five protocols with incrementally reduced BOLD contributions and analyzed the characteristics of resting-state networks and functional connectivity using model-free approaches. We report dfMRI data does not contain fundamentally different information to BOLD-fMRI, with the exception of a few regions that switch from anti- to positively-correlated. Future work will focus on removing any remaining BOLD contribution from the dfMRI acquisition.

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