Abstract #3613

Characterising tissue heterogeneity in cerebral metastases using multi-shell multi-tissue constrained spherical deconvolution

Maxime Chamberland¹, Najmus Sahar Iqbal^1,2, Suryanarayana Umesh Rudrapatna¹, Greg Parker¹, Chantal M.W. Tax¹, John Staffurth^2,3, James Powell², Richard Wise¹, and Derek K. Jones^1,4

¹School of Psychology, Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom, ²Velindre University NHS Trust, Velindre Cancer Centre, Cardiff, United Kingdom, ³Department of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, United Kingdom, ⁴School of Psychology, Australian Catholic University, Victoria, Australia

Considerable attention has focused on characterizing brain tumours using diffusion tensor imaging, and only more recently using advanced modelling techniques. Building on the observation that metastatic tumors exhibit different signal intensities depending on their histological/cellular composition, we investigate how multi-shell multi-tissue constrained spherical deconvolution can characterise tissue heterogeneity within brain metastases.

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