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Abstract #3614

Reproducibility of tractography based on fibre orientation distribution and anatomical constraints applied on paediatric diffusion MRI.

Thanh Vân Phan1,2, Thibo Billiet2, Dirk Smeets2, and Maaike Vandermosten1

1ExpORL, KU Leuven, Leuven, Belgium, 2Research and Development, icometrix, Leuven, Belgium

Tractography is known to be sensitive to technical variations but might also be sensitive to issues related to paediatric data, such as head motion. We assessed the reproducibility in paediatric data of the probabilistic tractography algorithm based on fibre orientation distribution and anatomical constraints that enables to deal with crossing fibres and to reconstruct tracts with more anatomical accuracy. Our results showed that the reproducibility of this approach when it is applied on paediatric data is negatively affected by younger age and by head motion but can still achieve good reproducibility for selected tracts.

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