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Abstract #3615

Cardiac Fiber Mobility During Contraction Using High Resolution Diffusion Tensor MRI

Kevin Moulin1, Ilya A Verzhbinsky1, Tyler E Cork1, Nyasha Maforo2,3, Luigi E Perotti2,4, and Daniel B Ennis1

1Radiological Sciences Lab, Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Radiological Sciences, University of California, Los Angeles, CA, United States, 3Physics and Biology in Medicine IDP, University of California, Los Angeles, CA, United States, 4Department of Bioengineering, University of California, Los angeles, CA, United States

The main cardiomyocyte aggregate orientation, represented by the Helix Angle, remains poorly described in vivo during contractionas it is affected by the imaging resolution and thus by a change of wall thickening. This work evaluated the effect of the imaging resolution using a numerical phantom and ex vivoscans on porcine hearts. High-resolution cDTI was acquired in vivoto measure the transmural mobility of Helix Angle at three cardiac phases. A strong steepening of Helix Angle was observed as the resolution decreased in simulation and ex-vivo. A significant change in the Helix Angle distribution was observed during contraction.

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