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Abstract #3616

Metabolite diffusion weighted imaging with golden angle radial echo planar spectroscopic imaging

Vincent Oltman Boer1, Itamar Ronen2, Jan Ole Pedersen3, Esben Thade Petersen1,4, and Henrik Lundell1

1Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 2C.J. Gorter Center for High Field MRI Research, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 3Philips Healthcare, Copenhagen, Denmark, 4Center for Magnetic Resonance, Department of Electrical Engineering, Technical University of Denmark, Lyngby, Denmark

Diffusion weighted spectroscopy (DWS) is a promising tool for investigating compartment specific microstructure in heterogeneous tissues. Unlike water abundant in all cellular spaces, the mobility of metabolites provides a window into the microstructure of specific cell types. Multi-shot sequences for diffusion spectroscopic imaging suffer from translation induced phase fluctuations. This has previously been addressed with additional phase navigators. In this work we propose self navigated metabolite diffusion weighted spectroscopic imaging using golden angle radial echo planar gradient readouts with semi-LASER voxel localization. Initial data shows good spatial localization and spectral quality.

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