Abstract #3618

Characterization of white matter asymmetries in the healthy human brain using diffusion MRI fixel-based analysis

Arush Honnedevasthana Arun^1,2, Robert E Smith¹, Alan Connelly^1,2, and Fernando Calamante^2,3,4

¹Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, ²Florey Department of Neuroscience and Mental health, Melbourne, Australia, ³The University of Sydney, Sydney Imaging, Sydney, Australia, ⁴The University of Sydney, School of Aerospace, Mechanical and Mechatronic Engineering, Sydney, Australia

The diffusion tensor model has been used extensively to study asymmetry in various regions of the human brain white matter. However, given the limitations of the tensor model, the nature of any underlying asymmetries remain uncertain, particularly in crossing fibre regions. Here, we applied fixel-based analysis (FBA) to state-of-the-art diffusion MRI data to assess white matter asymmetry of the healthy brain, demonstrating significant left/right asymmetries in various regions. The major advantage of this study is that FBA performs fibre-tract-specific modeling, and thus provides a method to assess the white matter asymmetry in a physically interpretable way.

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