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Abstract #3619

Toward prognostic sensitivity of DTI to cognitive outcomes following physical exercise interventions.

Anna Rita Egbert1, Ryan Falck1, John Best1, and Teresa Liu-Ambrose1,2

1Aging, Mobility and Cognitive Neuroscience Laboratory, University of British Columbia, Vancouver, BC, Canada, 2Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute and University of British Columbia, Vancouver, BC, Canada

Diffusion Tensor Imaging (DTI) is widely implemented in clinical research, yet, its prognostic value in brain and cognitive health remains uncertain. Prospective estimation of the effectiveness of interventions, such as physical exercise, can increase cost-effectiveness of treatment, thus, maximizing the impact of accessible modifiable preventive factors in improving health outcomes in the general population. We examined DTI in relationship to cognitive outcomes of physical activity intervention. This is the first study to show that white matter integrity related to sleep efficiency can be an early predictor of the cognitive outcomes of physical exercise intervention.

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