Abstract #3629

Application of Spinal Cord White Matter Tract Integrity Quantification with Atlas-based Analysis in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

Masaaki Hori¹, Akifumi Hagiwara^1,2, Kazumasa Yokoyama³, Kouhei Kamiya², Issei Fukunaga¹, Tomoko Maekawa^1,2, Koji Kamagata¹, Katsutoshi Murata⁴, Shohei Fujita^1,2, Ryusuke Irie^1,2, Christina Andica¹, Kanako Kunishima Kumamaru¹, Akihiko Wada¹, Julien Cohen-Adad⁵, and Shigeki Aoki¹

¹Radiology, Juntendo University School of Medicine, Tokyo, Japan, ²Radiology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, ³Neurology, Juntendo University School of Medicine, Tokyo, Japan, ⁴Siemens Japan K.K, Tokyo, Japan, ⁵NeuroPoly Lab, Polytechnique Montreal, Montreal, QC, Canada

We investigated both branches (Da ≤ De,∥ or Da > De,∥) of Kurtosis-based white matter tract integrity to distinguish microstructural changes in the spinal cords of patients with MS and Neuromyelitis Optica. FA and AWF were significant higher and MD was significant lower in spinal cord white matter in MS (P=0.009, 0.024, 0.032, respectively). Di,axial, Di,radial and De,radial of spinal cord white matter in MS were significant lower (P=0.009, 0.024, 0.032, respectively,) in Branch 2(Da > De,∥) in MS. There was no significant difference in Branch 1 ( Da ≤ De,∥) metrics.

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