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Abstract #3632

Tunable diffusion kurtosis in lamellar vesicle suspensions toward development of quantitative phantom surrogate of tumor microenvironment

Scott Swanson1, Dariya Malyarenko1, and Thomas Chenevert1

1Radiology, University of Michigan, Ann Arbor, MI, United States

A set of materials based on nanostructured lamellar vesicles with restricted diffusion compartments is constructed to achieve tunable diffusion kurtosis behavior. The observed apparent diffusion (Dapp) and kurtosis (Kapp) model parameters span the range of values found in vivo. Effect of vesicle population, size, and porosity is studied for estimated diffusion parameters. These nanostructured systems provide an ideal platform for a diffusion kurtosis phantom used to validate quantitative imaging protocols and results.

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