Abstract #3633

Simulation of Intravoxel Incoherent Perfusion Signal using a Realistic Capillary Network of a Mouse Brain

Valerie Phi van¹, Franca Schmidt², Linda Mathez³, Georg Spinner³, Sebastian Kozerke³, and Christian Federau³

¹University Hospital Zürich, Zürich, Switzerland, ²Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland, ³Institute for Biomedical Engineering, ETH and University of Zürich, Zürich, Switzerland

The microscopic origin of the IVIM perfusion signal is not well understood. We simulated blood motion in three realistic microvascular networks obtained by two-photon laser microscopy in mouse brain and computed the effect of this motion on the diffusion-weighted signal MR signal for b-values between 0 and 1000 s/mm2. We found pseudo-diffusion coefficients D* in the range of in vivo measurements. Further, the signal decay was strongly dependent on the specific type of vessel (capillary,arterioles/venules or pial vessels) and on the global vessel diameters of the network.

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