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Abstract #3634

Taxon anisotropic phantom delivering human scale parametrically controlled diffusion compartments to advance cross laboratory research and calibration.

Walter Schneider1, Sudhir Pathak1, Yijen Wu1, David Busch1, and John Dzikiy2

1University of Pittsburgh, Pittsburgh, PA, United States, 2Psychology Software Tools, Pittsburgh, PA, United States

Details a novel bi-component polymer Taxon (textile water filled tubes) anisotropic diffusion phantom providing 0.8 microndiameter tubes, packing density of 106 per mm2, water fraction of over 45% matched to human axon histology with parametric control of water compartment (intra/extra axon), size, density, angle dispersion that can be manufactured to supply hundreds of laboratories. Observed human tissue range FA (0.6-01.0), MD and RD in observed range. Providing ground truth measurement to advance and calibrate anisotropic diffusion measurement. Micro-CT and diffusion MRI indicate high water content in agreement with MRI and non MRI measurements.

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