Abstract #3641

Validation and Estimation of crossing angles of fiber bundle with different density using hollow textile-based phantom

Sudhir Kumar Pathak¹, Vinod Jangir Kumar², and Walter Schneider ^3,4

¹Learning Research and Development Center, University of Pittsburgh, Pittsburgh, PA, United States, ²Biological Cybernetics, Max Planck Institute, Tuebingen, Germany, ³Psychology, Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, ⁴Neurosurgery, Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States

A textile-based hollow fiber (taxon) MRI phantom (TABIP) is used to assess the ability of diffusion MR imaging (dMRI) to accurately estimate taxon crossing angles. A parametric pattern of known taxon crossings and taxon bundle sizes was manufactured in the TABIP phantom, it was scanned on a 3T scanner and data was reconstructed with a constrained spherical deconvolution algorithm. 21 repeated scans were collected to enhance SNR. Taxon crossing angles were estimated, and it is shown that crossing angles of 45° and higher can be accurately recovered and that angle measurement reliability decreases with bundle size.

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