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Abstract #3641

Validation and Estimation of crossing angles of fiber bundle with different density using hollow textile-based phantom

Sudhir Kumar Pathak1, Vinod Jangir Kumar2, and Walter Schneider 3,4

1Learning Research and Development Center, University of Pittsburgh, Pittsburgh, PA, United States, 2Biological Cybernetics, Max Planck Institute, Tuebingen, Germany, 3Psychology, Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, 4Neurosurgery, Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States

A textile-based hollow fiber (taxon) MRI phantom (TABIP) is used to assess the ability of diffusion MR imaging (dMRI) to accurately estimate taxon crossing angles. A parametric pattern of known taxon crossings and taxon bundle sizes was manufactured in the TABIP phantom, it was scanned on a 3T scanner and data was reconstructed with a constrained spherical deconvolution algorithm. 21 repeated scans were collected to enhance SNR. Taxon crossing angles were estimated, and it is shown that crossing angles of 45° and higher can be accurately recovered and that angle measurement reliability decreases with bundle size.

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