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Abstract #3642

Novel Atlas of Fiber Directions Built From Ex Vivo DT images of Porcine Hearts

Mia Mojica1, Mihaela Pop2, Maxime Sermesant3, and Mehran Ebrahimi1

1University of Ontario Institute of Technology, Oshawa, ON, Canada, 2Sunnybrook Research Institute, Toronto, ON, Canada, 3INRIA Sophia Antipolis, Sophia Antipolis, France

In this study we successfully created the first high-resolution cardiac Diffusion Tensor (DT) imaging-based fiber atlas from porcine hearts. Furthermore, we laid the foundation of a framework for building a statistical cardiac atlas by computing an average cardiac geometry from a small database (N=8) of explanted porcine hearts without the need for selecting landmarks, transforming the diffusion tensors of subjects, and obtaining the associated average DT field and fiber architecture. The fiber atlas can be used for personalized electro-mechanical simulations of cardiac function (in anisotropic models when DT data is not available), and aid in diagnosis or therapy guidance procedures.

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