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Abstract #3643

OGSE diffusion weighted imaging of epidermoid cysts: 3D Monte Carlo simulation

Saori Koshino1,2, Akiyuki Sakakibara3, Christina Andica2, Akifumi Hagiwara1,2, Masaaki Hori2, Osamu Abe1, and Shigeki Aoki2

1Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 3LPixel Inc., Tokyo, Japan

Diffusion weighted imaging with shorter diffusion time using oscillating gradient spin echo (OGSE) may reveal microstructural features among brain disorders. Here we observed DTI eigenvalues in four patients with epidermoid cysts. The values measured by OGSE were higher than those measured by pulsed gradient spin echo (PGSE; used in conventional MRI), indicating restricted diffusion due to spatial restriction and/or viscosity. The results of our Monte Carlo simulation based on the pathological feature of epidermoid cysts suggest that spatial restriction of multiple ellipsoids formed by keratin filaments as well as viscosity and water exchange should influence the extent of restricted diffusion.

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