Abstract #3644

Studying the effect of membrane permeability with a GPU-based Bloch–Torrey simulator

Jan N Rose¹, Lukasz Sliwinski¹, Sonia Nielles-Vallespin^2,3, Andrew D Scott^2,3,4, and Denis J Doorly¹

¹Department of Aeronautics, Imperial College London, London, United Kingdom, ²Cardiovascular Magnetic Resonance Unit, The Royal Brompton Hospital, London, United Kingdom, ³National Heart and Lung Institute, Imperial College London, London, United Kingdom, ⁴Data Science Institute, Imperial College London, London, United Kingdom

To better understand diffusion MRI in biological tissues, numerical simulations are commonly used to model the MR signal. Realistic simulation substrates built directly from histology images help to reduce the model error, but intrinsic parameters other than the microstructure have an effect too. In this study, we investigate the relationship between diffusion tensor fractional anisotropy and membrane permeability. Using a GPU-accelerated Bloch–Torrey solver, we observe a significant difference from the impermeable case for long diffusion times on the order of 1s.

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