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Abstract #3655

Validation of Diffusion Imaging Measures in Gray Matter using Histology from macaque monkey

Madhura Baxi1,2, Suheyla Cetin Karayumak2, Doug Richardson3, George Papadimitriou4, Sarina Karmacharya2, Nikos Makris2, Andre van der Kouwe5, Bruce Jenkins5, Thomas Witzel5, Tara Moore6, Douglas Rosene6, Marek Kubicki2, and Yogesh Rathi2

1Graduate Program for Neuroscience, Boston University, Boston, MA, United States, 2Psychiatry NeuroImaging Lab, HMS, BWH, Boston, MA, United States, 3Harvard Center for Biological Imaging, Harvard University, Cambridge, MA, United States, 4Center for Morphometric Analysis, Massachusetts General Hospital, Charlestown, MA, United States, 5Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 6Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, United States

This study is the first attempt towards histological validation of diffusion imaging measure of Trace in the gray matter of macaque monkey. Heterogeneity of Trace (hTrace) computed for one monkey in 7 cytoarchitectonically different regions was compared with the variance in intracellular volume fraction for the same regions computed using digitized histological sections, stained for all cell bodies. hTrace was found to be significantly correlated with the variance in intracellular volume fraction. This shows that the diffusion measure of hTrace is sensitive to the underlying gray matter cytoarchitecture such as the cell size and cell packing density.

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