Free water eliminated diffusion tensor imaging (fwDTI) and neurite orientation dispersion and density imaging (NODDI) are two increasingly established techniques that measure free water (FW) in diffusion MRI. Yet, despite the utility of each approach, their corresponding FW estimates have yet to be compared. In this work, we find that FW measurements near cerebrospinal fluid are highly similar between the two approaches, but within tissue, NODDI tends to compute slightly higher FW values in the white matter and lower FW values in gray matter than fwDTI. Potential sources of this discrepancy are discussed.
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